BIOANALYTICAL CHEMISTRY Development and validation of analytical methods (plasma, urine, tissues, milk…) Analytical assays for pharmacokinetic, metabolism and residue studies Biochemical and immunological analysis, lipoprotein profiles PHARMACOKINETICS Bioavailability Bioequivalence Single and multiple-dose pharmacokinetics Linearity Dose ranging Toxicokinetics Pharmacokinetic evaluation of data : compartmental and non-compartmental analysis METABOLISM - Absorption, Distribution, Metabolism and Elimination (ADME) Mass Balance / Excretion Biliary Excretion – Enterohepatic recirculation Tissue Distribution Metabolite profiling and identification Dose analysis : Radiochemical purity and specific activity - In vitro Protein binding S9, microsomes, hepatocytes, inductions (inhibition studies, Caco-2 cells in partnership) RESIDUE STUDIES - Residue depletion in food-producing species ECOTOXICITY - Ecotoxicological studies : Phase I & Phase II Degradation studies (manure, slung, etc...) Adsorption desorption studies (soils)